GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs9394931 | 1 | rs9394931 | chr6:42873245 | PEX6 | chr6:42931613-42946981:- | -0.44 | -7.19 | 3.4E-12 | Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) |
| BLCA | cis | rs9369898 | 1 | rs9395493 | chr6:49427409 | CENPQ | chr6:49431096-49460820:+ | -0.41 | -8.83 | 3.75E-17 | Homocysteine levels |
| BLCA | cis | rs9815354 | 1 | rs939558 | chr3:41976040 | ULK4 | chr3:41288091-42003660:- | -0.63 | -9.71 | 4.41E-20 | Diastolic blood pressure |
| BLCA | cis | rs9371538 | 1 | rs9397425 | chr6:151873024 | C6orf97 | chr6:151815175-151942327:+ | 0.26 | 3.91 | 0.000111 | Bone mineral density (spine) |
| BLCA | cis | rs9371538 | 1 | rs9397428 | chr6:151875080 | C6orf97 | chr6:151815175-151942327:+ | 0.26 | 3.91 | 0.000111 | Bone mineral density (spine) |
| BLCA | cis | rs9371538 | 1 | rs9397429 | chr6:151877569 | C6orf97 | chr6:151815175-151942327:+ | 0.29 | 4.23 | 2.88E-5 | Bone mineral density (spine) |
| BLCA | cis | rs9371538 | 1 | rs9397431 | chr6:151883930 | C6orf97 | chr6:151815175-151942327:+ | 0.3 | 4.47 | 1.05E-5 | Bone mineral density (spine) |
| BLCA | cis | rs9322193 | 1 | rs9399693 | chr6:149933854 | NUP43 | chr6:150045453-150067688:- | -0.25 | -4.09 | 5.29E-5 | Lung cancer |
| BLCA | cis | rs2143950 | 1 | rs941653 | chr14:35592538 | PPP2R3C | chr14:35554679-35591679:- | 0.25 | 4.05 | 6.12E-5 | Atopic dermatitis |
| BLCA | cis | rs9425766 | 1 | rs9425766 | chr1:173853127 | ANKRD45 | chr1:173577475-173639001:- | 0.26 | 4.31 | 2.07E-5 | Life satisfaction |
| BLCA | cis | rs2275426 | 1 | rs9429183 | chr1:46524582 | CCDC163P | chr1:45960581-45965646:- | -0.33 | -6.25 | 1.1E-9 | Body mass index |
| BLCA | cis | rs7528684 | 1 | rs945635 | chr1:157670290 | FCRL3 | chr1:157646278-157670775:- | 0.29 | 9.27 | 1.4E-18 | Type 1 diabetes autoantibodies |
| BLCA | cis | rs9457247 | 1 | rs9457247 | chr6:167392174 | RNASET2 | chr6:167343008-167412795:- | -0.24 | -5.04 | 7.23E-7 | Crohn's disease |
| BLCA | cis | rs9473555 | 1 | rs9463473 | chr6:49380121 | CENPQ | chr6:49431096-49460820:+ | -0.27 | -5.63 | 3.5E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs9463473 | chr6:49380121 | MUT | chr6:49398994-49431031:- | 0.28 | 5.53 | 5.97E-8 | Folate pathway vitamin levels |